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KMID : 1149220200280040313
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Korean Journal of Oriental Medical Prescription
2020 Volume.28 No. 4 p.313 ~ p.325
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Network pharmacological analysis for exploration of the potential application of Hwangryunhaedok-tang for brain diseases
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Lee Se-Eun
Lim Jae-Yu
Chung Byung-Woo
Lee Byoung-Ho
Lim Jung-Hwa
Cho Su-In
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Abstract
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Objectives : To explore the associated potential pathways and molecular targets of Hwangryunhaedok-tang(HHT) by the approaches of network pharmacology and bioinformatics in traditional chinese medicine(TCM).
Methods : Hwangryunhaedok-tang constituent drugs(Coptidis Rhizoma, CR; Scutellariae Radix, SR; Phellodendri Cortex, PC; Gardeniae Fructus, GF) and their processing types were searched from TCM systems pharmacology(TCMSP). The databases of TCMSP, Kyoto Encyclopedia of Genes and Genomes(KEGG), MCODE and STRING were used to gather information. The network of bioactive ingredients and target gene was constructed by Cytoscape software(version 3.8).
Results : A total of 94 HHT active compounds(CR, 12; SR, 35; PC, 33; GF, 14, respectively) were found, and HHT were identified by TCMSP. Applications of KEGG and MCODE analysis indicates that total of 6 bioactive ingredients in the top 10% ranking were obtained and 32 diseases of HHT were screened. The molecular pathway analysis revealed that HHT exerts cancer, inflammation and cerebrovascular diseases effects by acting on several signaling pathway. In addition, HHT found that three genes(e.g. SPIN1, TRIM25, and APP) correlate with the aforementioned diseases.
Conclusions : This study showed that network pharmacology analysis is useful to elucidate the complex mechanisms of action of HHT.
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KEYWORD
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Hwangryunhaedok-tang, traditional medicine, systems pharmacology, drug discovery
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